The effects of the five extracts from Herba pogostmonis being gotten rid of volatile oil on gastrointestinal tract were studied. The results showed that the five extracts could increase gastric secretion of acid and activity of pepsin, reduce the incidence of diarrhea induced by Folium sennae and relieve the gripping pain induced by abdominal administration of acetic acid. The extract of ethyl acetate could also inhibit the normal and neostigmine induced mice intestinal propellant movement. The effect of extract of ethyl acetate was consistent with clinical application. The above results indicated that the clinical effect of Herba pogostmonis may be comprehensive action of above five different polar extracts.