Characterisation of thymus-derived regulatory T cells that protect against organ-specific autoimmune disease

L A Stephens; D Mason

doi:10.1016/s1286-4579(01)01451-4

Characterisation of thymus-derived regulatory T cells that protect against organ-specific autoimmune disease

Microbes Infect. 2001 Sep;3(11):905-10. doi: 10.1016/s1286-4579(01)01451-4.

Authors

L A Stephens¹, D Mason

Affiliation

¹ Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

PMID: 11564438
DOI: 10.1016/s1286-4579(01)01451-4

Abstract

Immunological tolerance to self is, in part, an active process mediated by a certain population of T lymphocytes. Our own work on the origin, phenotypic characterisation and mode of action of these regulatory T cells in rats forms the main focus of this review.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autoimmune Diseases / immunology*
Disease Models, Animal
Down-Regulation
Humans
Organ Specificity
Rats
Self Tolerance
T-Lymphocytes / immunology*
Thymus Gland / cytology*