Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells

Microbes Infect. 2001 Sep;3(11):919-27. doi: 10.1016/s1286-4579(01)01453-8.


CD4(+)CD25(+) T cells regulate the activity of autoreactive T cells. Depletion of these cells results in the development of a wide-spectrum of organ-specific autoimmune diseases. In vitro model systems have been developed to study the function of these potent suppressor cells. Following their activation via their T-cell receptor, they downregulate the responses of CD25(-) effectors by a T-T interaction.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / prevention & control
  • CD4-Positive T-Lymphocytes / immunology*
  • Disease Models, Animal
  • Down-Regulation / immunology
  • Gastritis / immunology*
  • Gastritis / prevention & control
  • Humans
  • Mice
  • Organ Specificity / immunology*
  • Receptors, Interleukin-2 / metabolism*
  • T-Lymphocyte Subsets / immunology


  • Receptors, Interleukin-2