Combined transplantation of the heart, lung, and liver

Lancet. 2001 Sep 8;358(9284):812-3. doi: 10.1016/S0140-6736(01)06003-2.


Combined transplantation of the heart, lung, and liver may be indicated in patients with either end-stage respiratory failure complicated by advanced liver disease or end-stage liver failure complicated by advanced lung disease. A retrospective review of nine patients who underwent combined heart-lung-liver transplantation in Cambridge (1986-99) was carried out. The 1-year and 5-year actuarial survival was 56% and 42%, respectively. Combined heart-lung-liver transplantation is a feasible option for a few patients and has a 5-year survival similar to heart-lung transplantation but with a lower incidence of acute and chronic rejection.

Publication types

  • Letter

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cause of Death
  • Child
  • Female
  • Graft Survival
  • Heart Transplantation*
  • Humans
  • Liver Transplantation*
  • Lung Transplantation*
  • Male
  • Middle Aged
  • Postoperative Period
  • Retrospective Studies
  • Survival Analysis
  • Treatment Outcome