Biofilm formation: a clinically relevant microbiological process

Clin Infect Dis. 2001 Oct 15;33(8):1387-92. doi: 10.1086/322972. Epub 2001 Sep 20.


Microorganisms universally attach to surfaces and produce extracellular polysaccharides, resulting in the formation of a biofilm. Biofilms pose a serious problem for public health because of the increased resistance of biofilm-associated organisms to antimicrobial agents and the potential for these organisms to cause infections in patients with indwelling medical devices. An appreciation of the role of biofilms in infection should enhance the clinical decision-making process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / growth & development
  • Biofilms / growth & development*
  • Candida albicans / growth & development
  • Catheters, Indwelling / microbiology*
  • Equipment Contamination*
  • Equipment and Supplies, Hospital / microbiology*
  • Humans