Vasa homolog genes in mammalian germ cell development

Cell Struct Funct. 2001 Jun;26(3):131-6. doi: 10.1247/csf.26.131.


Many vasa homologue genes to Drosophila vasa have been isolated in various animal species. They provide specific molecular probes to analyze the establishment and the differentiation of germ cell lineage. In mammals, the expression of VASA protein becomes detectable in PGCs at the late migrating stage. Interestingly, during spermatogenesis the intracellular localization of VASA protein is closely associated with the chromatoid body.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DEAD-box RNA Helicases
  • Female
  • Germ Cells / metabolism
  • Germ Cells / physiology*
  • Humans
  • Male
  • Mice
  • Molecular Sequence Data
  • Oogenesis / genetics
  • RNA Helicases / analysis
  • RNA Helicases / genetics*
  • Rats
  • Sequence Homology
  • Spermatogenesis / genetics


  • DDX4 protein, human
  • DEAD-box RNA Helicases
  • RNA Helicases