Angiopoietin and Tie signaling pathways in vascular development

Matrix Biol. 2001 Sep;20(5-6):319-25. doi: 10.1016/s0945-053x(01)00149-4.


The angiopoietin ligands and Tie receptors belong to a novel class of ligand/receptor families, which play critical roles in blood vessel formation. They are considered to control numerous signaling pathways that are involved in diverse cellular processes, such as cell migration, proliferation and survival, and reorganization of the actin cytoskeleton. In this review, we summarize the important biochemical and biological properties of this interesting ligand/receptor family. Particular emphasis will be made on potential downstream targets and consequences of the endothelial cell behavior, due to regulation by the angiopoietin/Tie pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Angiopoietin-1
  • Angiopoietin-2
  • Animals
  • Blood Vessels / growth & development*
  • Blood Vessels / metabolism
  • Blood Vessels / pathology
  • Endothelium / cytology
  • Humans
  • Membrane Glycoproteins / metabolism*
  • Neoplasm Proteins / metabolism*
  • Proteins / metabolism*
  • Proto-Oncogene Proteins*
  • Signal Transduction / physiology


  • Angiopoietin-1
  • Angiopoietin-2
  • MEN1 protein, human
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Proteins
  • Proto-Oncogene Proteins