The role of collagen-derived proteolytic fragments in angiogenesis

Matrix Biol. 2001 Sep;20(5-6):337-45. doi: 10.1016/s0945-053x(01)00151-2.


Basement membrane molecules and fragments derived from them are regulators of biological activities such as cell growth, differentiation and migration. This review describes proteolytically derived fragments from the non-collagenous (NC1) domain at the C-terminus of the basement membrane collagens type IV, XV and XVIII, which have been implicated as regulators of angiogenesis. Endostatin is an endogenous collagen XVIII/NC1 derivative, inhibiting endothelial cell proliferation and migration in vitro and tumor-growth in vivo. A homologous NC1 domain fragment of type XV collagen has anti-angiogenic activity as well. Furthermore, NC1 domain fragments of the most abundant basement membrane collagen, type IV collagen, have been shown to inhibit induced vessel growth.

Publication types

  • Review

MeSH terms

  • Animals
  • Collagen / metabolism*
  • Collagen Type IV / metabolism*
  • Collagen Type XVIII
  • Endostatins
  • Humans
  • Hydrolysis
  • Neovascularization, Physiologic / physiology*
  • Peptide Fragments / metabolism*
  • Protein Structure, Tertiary / physiology


  • COL15A1 protein, human
  • Collagen Type IV
  • Collagen Type XVIII
  • Endostatins
  • Peptide Fragments
  • Collagen