Detection of a novel t(6;15)(q21;q21) in a pediatric Wilms tumor

Cancer Genet Cytogenet. 2001 Sep;129(2):165-7. doi: 10.1016/s0165-4608(01)00445-9.


We report a novel cytogenetic finding in a favorable histology Wilms tumor occurring in a 4-month-old boy. Karyotypic analysis demonstrated a t(6;15)(q21;q21) in all tumor cells examined. This was confirmed using fluorescence in situ hybridization analysis. Molecular analysis of this rearrangement may provide clues to understanding the pathobiology of Wilms tumor.

Publication types

  • Case Reports

MeSH terms

  • Chromosome Painting
  • Chromosomes, Human, Pair 15 / genetics*
  • Chromosomes, Human, Pair 6 / genetics*
  • European Continental Ancestry Group / genetics
  • Humans
  • In Situ Hybridization, Fluorescence
  • Infant
  • Karyotyping
  • Male
  • Ploidies
  • Translocation, Genetic / genetics*
  • Tumor Cells, Cultured
  • Wilms Tumor / diagnosis
  • Wilms Tumor / genetics*
  • Wilms Tumor / therapy