Peptide aptamers: new tools to study protein interactions

J Steroid Biochem Mol Biol. 2001 Aug;78(2):105-11. doi: 10.1016/s0960-0760(01)00085-1.

Abstract

The ability to specifically interfere with the function of proteins of pathological significance has been a goal for molecular medicine for many years. Peptide aptamers comprise a new class of molecules, with a peptide moiety of randomized sequence, which are selected for their ability to bind to a given target protein under intracellular conditions. They have the potential to inhibit the biochemical activities of a target protein, can delineate the interactions of the target protein in regulatory networks, and identify novel therapeutic targets. Peptide aptamers represent a new basis for drug design and protein therapy, with implications for basic and applied research, for a broad variety of different types of diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiviral Agents / pharmacology
  • CDC2-CDC28 Kinases*
  • Cell Cycle Proteins*
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • DNA-Binding Proteins*
  • Drug Design
  • E2F Transcription Factors
  • Oncogene Proteins, Viral / antagonists & inhibitors
  • Peptides / pharmacology*
  • Peptides / therapeutic use
  • Protein Binding / drug effects*
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors
  • Transcription Factors / antagonists & inhibitors
  • Viral Core Proteins / antagonists & inhibitors

Substances

  • Antiviral Agents
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • Oncogene Proteins, Viral
  • Peptides
  • Transcription Factors
  • Viral Core Proteins
  • nucleocapsid protein, Hepatitis C virus
  • Protein-Serine-Threonine Kinases
  • CDC2-CDC28 Kinases
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinases