Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis

Cancer Lett. 2001 Oct 30;172(2):193-8. doi: 10.1016/s0304-3835(01)00652-8.


We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro. The D-Fraction also increased plasma vascular endothelial growth factor (VEGF) concentration significantly. Also VEGF and TNF-alpha production by the activated peritoneal macrophages were enhanced. These results suggest that the anti-tumor activity of the D-Fraction is not only associated with the activation of the immuno-competent cells but also possibly related to the carcinoma angiogenesis induction.

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Endothelial Growth Factors / biosynthesis
  • Endothelial Growth Factors / blood
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects
  • Fungal Proteins / pharmacology*
  • Glycoproteins / pharmacology*
  • Humans
  • Lymphokines / biosynthesis
  • Lymphokines / blood
  • Male
  • Mice
  • Mice, Inbred C3H
  • Neoplasms, Experimental / blood supply*
  • Neoplasms, Experimental / drug therapy
  • Neovascularization, Pathologic / chemically induced*
  • Polyporaceae / chemistry*
  • Tumor Necrosis Factor-alpha / biosynthesis
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors


  • Antineoplastic Agents
  • Endothelial Growth Factors
  • Fungal Proteins
  • Glycoproteins
  • Lymphokines
  • Tumor Necrosis Factor-alpha
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors