The IGF system and breast cancer

Endocr Relat Cancer. 2001 Sep;8(3):197-209. doi: 10.1677/erc.0.0080197.

Abstract

The IGF system components have been implicated in breast cancer progression. IGF-I and IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell types including normal and transformed breast epithelial cells. The IGF system is a key growth regulatory pathway in breast cancer. As various components of the IGF system have been directly or indirectly implicated in breast cancer, it is essential to gain a better understanding of these in order to develop more specific therapeutic strategies for treating breast cancer.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / metabolism*
  • Female
  • Humans
  • Insulin-Like Growth Factor Binding Proteins / metabolism
  • Insulin-Like Growth Factor I / metabolism*
  • Insulin-Like Growth Factor II / metabolism*

Substances

  • Insulin-Like Growth Factor Binding Proteins
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II