Injections in the treatment of osteoarthritis

Best Pract Res Clin Rheumatol. 2001 Oct;15(4):609-26. doi: 10.1053/berh.2001.0177.


Injections, especially of corticosteroids but also of hyaluronan, are widely used in the treatment of osteoarthritis. The various joints - knee, hip, hand - affected by OA are accessible to these local treatments. This chapter concentrates on the evidence for efficacy of these treatments and attempts to delimit their respective indications and optimal doses. The side-effects of corticosteroid injections are reviewed, and the potential interest in post-injection rest is discussed. Finally, the potential structure-modifying effect of hyaluronan is investigated.

Publication types

  • Review

MeSH terms

  • Bed Rest
  • Drug Administration Schedule
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / therapeutic use*
  • Humans
  • Hyaluronic Acid / therapeutic use*
  • Injections, Intra-Articular
  • Middle Aged
  • Osteoarthritis, Knee / drug therapy*
  • Pain / drug therapy
  • Randomized Controlled Trials as Topic
  • Treatment Outcome


  • Glucocorticoids
  • Hyaluronic Acid