Ventral neurogenesis and the neuron-glial switch

Neuron. 2001 Sep 13;31(5):677-80. doi: 10.1016/s0896-6273(01)00430-5.


In the developing spinal cord, neuroepithelial precursors at different positions along the dorsal-ventral axis generate distinct neuronal and glial subtypes. For example, one group of ventral precursors generates neurons followed by oligodendrocytes. A spate of recent articles, including several in this issue of Neuron, are devoted to the mechanisms governing neuronal and glial subtype specification in the ventral cord. We review these studies and discuss the nature of the ventral neuron-oligodendrocyte switch.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology*
  • Gene Expression Regulation, Developmental / physiology
  • Homeodomain Proteins / physiology
  • Humans
  • Neurons / cytology
  • Neurons / physiology*
  • Oligodendroglia / cytology
  • Oligodendroglia / physiology
  • Spinal Cord / cytology
  • Spinal Cord / embryology*
  • Spinal Cord / physiology
  • Stem Cells / cytology
  • Stem Cells / physiology


  • Homeodomain Proteins