Asymmetric inheritance of radial glial fibers by cortical neurons

Neuron. 2001 Sep 13;31(5):727-41. doi: 10.1016/s0896-6273(01)00420-2.


Recent studies demonstrated the neuronogenic role of radial glial cells (RGCs) in the rodent. To reveal the fate of radial glial processes, we intensively monitored divisions of RGCs in DiI-labeled slices from the embryonic day 14 mouse cortex. During RGC division, each pia-connected fiber becomes thin but is neither lost nor divided; it is inherited asymmetrically by one daughter cell. In divisions that produce a neuron and a progenitor, the neuron inherits the pial fiber, also grows a thick ventricular process for several hours, and is therefore indistinguishable from the progenitor RGC. The ventricular process in the radial glial-like neuron ("radial neuron") then collapses, leading to ascent of the neuron by using the "recycled" radial fiber.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology
  • Animals
  • Body Patterning / physiology
  • Cell Compartmentation / physiology
  • Cell Differentiation / physiology*
  • Cell Division / physiology*
  • Cell Lineage / physiology
  • Cell Movement / physiology*
  • Cell Size / physiology
  • Cerebral Cortex / cytology
  • Cerebral Cortex / embryology*
  • Cerebral Cortex / metabolism
  • Fetus
  • Immunohistochemistry
  • Mice
  • Mice, Inbred ICR
  • Nerve Tissue Proteins / metabolism
  • Neurites / metabolism
  • Neurites / ultrastructure
  • Neuroglia / cytology*
  • Neuroglia / metabolism
  • Neurons / cytology*
  • Neurons / metabolism
  • Organ Culture Techniques
  • Stem Cells / cytology*
  • Stem Cells / metabolism


  • Nerve Tissue Proteins