Abstract
The COP9 signalosome is an evolutionarily conserved multiprotein complex that was first identified as an essential complex that represses light-regulated development in Arabidopsis. The COP9 signalosome has similarity to the lid of the 19S regulatory particle of the 26S proteasome and has recently been shown to interact with SCF-type E3 ubiquitin ligases. Although its precise role in the process of protein degradation remains to be established, the COP9 signalosome is a positive regulator of E3 ubiquitin ligases that functions at least in part by mediating the deconjugation of the NEDD8/RUB-modification from the cullin subunit of SCF-type E3 complexes. Here, we discuss these recent findings, which add an additional component to the biology of substrate-specific protein degradation.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Review
MeSH terms
-
Animals
-
Arabidopsis
-
Arabidopsis Proteins
-
COP9 Signalosome Complex
-
Drosophila / metabolism
-
Drosophila Proteins
-
Humans
-
Ligases / metabolism
-
Models, Biological
-
Multiprotein Complexes
-
NEDD8 Protein
-
Peptide Hydrolases / chemistry
-
Peptide Hydrolases / metabolism
-
Proteasome Endopeptidase Complex*
-
Protein Structure, Tertiary
-
Protein Subunits
-
Proteins / chemistry
-
Proteins / genetics
-
Proteins / metabolism*
-
Proteins / physiology*
-
Schizosaccharomyces
-
Signal Transduction
-
Ubiquitin-Protein Ligases
-
Ubiquitins / metabolism*
Substances
-
Arabidopsis Proteins
-
Drosophila Proteins
-
Multiprotein Complexes
-
NEDD8 Protein
-
NEDD8 protein, human
-
Nedd8 protein, Drosophila
-
Protein Subunits
-
Proteins
-
RUB1 protein, Arabidopsis
-
Ubiquitins
-
Ubiquitin-Protein Ligases
-
Peptide Hydrolases
-
COP9 Signalosome Complex
-
Proteasome Endopeptidase Complex
-
ATP dependent 26S protease
-
Ligases