Integrating stress-response and cell-cycle checkpoint pathways

Trends Cell Biol. 2001 Oct;11(10):426-33. doi: 10.1016/s0962-8924(01)02119-5.

Abstract

The DNA integrity checkpoint and stress kinase (SAPK/JNK and p38) pathways function to modulate cell-cycle, apoptotic and transcriptional responses to stress. Although initially considered to function independently, recent advances indicate a number of links between the stress-response and checkpoint pathways. Here, we consider the relationship between the stress-response and checkpoint pathways and how they interact to modulate cell-cycle control.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cell Cycle / physiology*
  • Checkpoint Kinase 1
  • Checkpoint Kinase 2
  • DNA Damage
  • DNA Replication / physiology
  • MAP Kinase Signaling System
  • Models, Biological
  • Oxidative Stress / physiology*
  • Phosphorylation
  • Protein Kinases / metabolism
  • Protein Kinases / physiology
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Signal Transduction
  • Transcription, Genetic
  • Yeasts

Substances

  • Protein Kinases
  • Checkpoint Kinase 2
  • Checkpoint Kinase 1
  • Protein-Serine-Threonine Kinases