Language and spatial attention can lateralize to the same hemisphere in healthy humans

Neurology. 2001 Sep 25;57(6):1018-24. doi: 10.1212/wnl.57.6.1018.


Background: Disorders of language classically occur after left brain lesions, and disorders of spatial attention after right brain lesions. It is unclear whether the hemispheric dissociation of functions is a fixed pattern of brain organization.

Objective: The authors determined whether lateralization of language and lateralization of spatial attention also dissociate in people with atypical (i.e., right hemispheric) language dominance.

Methods: The authors selected 10 subjects with typical, i.e., left hemispheric, and 10 with atypical, i.e., right hemispheric, language representation on a random basis from a sample of 326 healthy volunteers examined with functional transcranial Doppler sonography (fTCD) for language dominance. In these subjects, hemispheric lateralization of cerebral perfusion during a line bisection task was determined with fTCD.

Results: The authors found a dissociation between dominance for language and spatial attention in all but four subjects. In the latter subjects, there was a significant lateralization to the right hemisphere for both tasks. The four subjects showed normal intellectual, linguistic, and spatial performance, with normal EEG and MRI scans of the brain.

Conclusion: Even in the absence of brain pathology, the same hemisphere can be dominant in control of both language and spatial attention.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Attention / physiology*
  • Brain Mapping
  • Cerebral Cortex / blood supply
  • Cerebral Cortex / physiology*
  • Dominance, Cerebral / physiology*
  • Electroencephalography
  • Female
  • Humans
  • Language Tests*
  • Magnetic Resonance Imaging
  • Male
  • Orientation / physiology*
  • Reading
  • Reference Values
  • Semantics
  • Ultrasonography, Doppler, Transcranial
  • Verbal Behavior / physiology*