Adrenomedullin and proadrenomudullin N-terminal 20 peptide (PAMP) are present in human colonic epithelia and exert an antimicrobial effect

Exp Physiol. 2001 Sep;86(5):543-5. doi: 10.1113/eph8602250.

Abstract

The hypotensive and vasorelaxing peptides adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), were found to be distributed on the surface of the colonic mucosa. AM and PAMP showed dose-dependent antimicrobial activity against E. coli. The results suggest that the novel vasoactive peptides AM and PAMP play an important role in mucosal defence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenomedullin
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Colon / chemistry*
  • Escherichia coli / drug effects
  • Humans
  • Immunohistochemistry
  • Intestinal Mucosa / chemistry*
  • Intestinal Mucosa / cytology
  • Peptide Fragments / analysis*
  • Peptide Fragments / pharmacology
  • Peptides / analysis*
  • Peptides / pharmacology
  • Proteins / analysis*
  • Proteins / pharmacology
  • Vasodilator Agents / analysis
  • Vasodilator Agents / pharmacology

Substances

  • Anti-Bacterial Agents
  • Peptide Fragments
  • Peptides
  • Proteins
  • Vasodilator Agents
  • Adrenomedullin