Antidiuretic hormone. Normal and disordered function

Endocrinol Metab Clin North Am. 2001 Sep;30(3):671-94, vii. doi: 10.1016/s0889-8529(05)70207-3.


In humans and most other mammals, the antidiuretic hormone (ADH) is a nonapeptide often referred to as arginine vasopressin (AVP). It is produced by large neurons that originate in the supraoptic and paraventricular nucleus of the hypothalamus and project through the pituitary stalk to terminate on capillary plexuses scattered throughout the posterior pituitary. These plexuses drain into the systemic circulation by way of the cavernous sinus and superior vena cava.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Arginine Vasopressin / deficiency
  • Arginine Vasopressin / metabolism
  • Arginine Vasopressin / physiology
  • Humans
  • Hypernatremia / etiology
  • Hypernatremia / physiopathology
  • Hypernatremia / therapy
  • Inappropriate ADH Syndrome / etiology
  • Inappropriate ADH Syndrome / physiopathology
  • Inappropriate ADH Syndrome / therapy
  • Vasopressins / deficiency
  • Vasopressins / metabolism
  • Vasopressins / physiology*


  • Vasopressins
  • Arginine Vasopressin