Switching and Signaling at the Telomere

Cell. 2001 Sep 21;106(6):661-73. doi: 10.1016/s0092-8674(01)00492-5.

Abstract

This review describes the structure of telomeres, the protective DNA-protein complexes at eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere functions. Also discussed are cellular responses to compromising the functions of telomeres and of telomerase, which synthesizes telomeric DNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA Replication
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • Humans
  • Models, Genetic
  • Saccharomyces cerevisiae / genetics
  • Signal Transduction
  • Telomerase / metabolism*
  • Telomere / physiology*
  • Telomere / ultrastructure*

Substances

  • DNA-Binding Proteins
  • Telomerase