Serial regulation of transcriptional regulators in the yeast cell cycle

Cell. 2001 Sep 21;106(6):697-708. doi: 10.1016/s0092-8674(01)00494-9.


Genome-wide location analysis was used to determine how the yeast cell cycle gene expression program is regulated by each of the nine known cell cycle transcriptional activators. We found that cell cycle transcriptional activators that function during one stage of the cell cycle regulate transcriptional activators that function during the next stage. This serial regulation of transcriptional activators forms a connected regulatory network that is itself a cycle. Our results also reveal how the nine transcriptional regulators coordinately regulate global gene expression and diverse stage-specific functions to produce a continuous cycle of cellular events. This information forms the foundation for a complete map of the transcriptional regulatory network that controls the cell cycle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Cycle / genetics*
  • Cyclin-Dependent Kinases / genetics
  • Cyclins / genetics
  • Gene Expression Regulation, Fungal*
  • Genome, Fungal
  • Saccharomyces cerevisiae / cytology*
  • Saccharomyces cerevisiae / genetics*
  • Trans-Activators / metabolism*
  • Transcription Factors / metabolism*


  • Cyclins
  • Trans-Activators
  • Transcription Factors
  • Cyclin-Dependent Kinases