Molecular biology of the chromo domain: an ancient chromatin module comes of age

Gene. 2001 Sep 5;275(1):19-29. doi: 10.1016/s0378-1119(01)00628-x.

Abstract

The chromo domain motif is found in proteins from fungi, protists, plants, fish, insects, amphibians, birds, and mammals. The chromo domain peptide fold may have its origins as a chromosomal protein in a common ancestor of archea and eukaryota, making it a particularly ancient protein structural module. Chromo domains have been found in single or multiple copies in proteins with diverse structures and activities, most or all of which are connected with chromosome structure/function. In this review, our current knowledge of chromo domain properties is summarized and a variety of contexts in which chromo domains participate in aspects of chromatin metabolism are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromatin / genetics*
  • Chromosomal Proteins, Non-Histone / chemistry
  • Chromosomal Proteins, Non-Histone / genetics
  • DNA Helicases
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • Drosophila Proteins*
  • Evolution, Molecular
  • Fungal Proteins / chemistry
  • Fungal Proteins / genetics
  • Gene Expression Regulation
  • Humans
  • Insect Proteins / chemistry
  • Insect Proteins / genetics
  • Molecular Sequence Data
  • Polycomb Repressive Complex 1
  • Protein Structure, Tertiary / genetics
  • Proteins / chemistry
  • Proteins / genetics*
  • Saccharomyces cerevisiae Proteins*
  • Sequence Homology, Amino Acid
  • Transcription Factors / chemistry
  • Transcription Factors / genetics

Substances

  • CHD1 protein, S cerevisiae
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Fungal Proteins
  • Insect Proteins
  • Pc protein, Drosophila
  • Proteins
  • SWI6 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • heterochromatin-specific nonhistone chromosomal protein HP-1
  • Polycomb Repressive Complex 1
  • DNA Helicases
  • CHD1 protein, human