Abstract
Three new 12beta-hydroxymultiflorane triterpenoid acids, sandorinic acids A-C (1-3), were isolated from the stem bark of Sandoricum indicum together with five known triterpenes (4-8). The structures of 1-3 were elucidated by spectral data interpretation. Compounds 1-8 were evaluated for their inhibiting activity against several tumor cell lines and for their effects on lymphocyte proliferation.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Chromatography
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Chromatography, High Pressure Liquid
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Doxorubicin / pharmacology
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Drug Resistance, Neoplasm
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Leukemia P388
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Leukemia, Lymphoid
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Magnetic Resonance Spectroscopy
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Medicine, Chinese Traditional
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Meliaceae / chemistry*
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Mice
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Molecular Structure
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Plant Stems / chemistry
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Plants, Medicinal / chemistry
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Structure-Activity Relationship
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Thailand
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
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Tumor Cells, Cultured / drug effects
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Vincristine / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Triterpenes
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sandorinic acid A
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sandorinic acid B
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sandorinic acid C
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Vincristine
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Doxorubicin