New multiflorane-type triterpenoid acids from Sandoricum indicum

J Nat Prod. 2001 Sep;64(9):1243-5. doi: 10.1021/np010196w.

Abstract

Three new 12beta-hydroxymultiflorane triterpenoid acids, sandorinic acids A-C (1-3), were isolated from the stem bark of Sandoricum indicum together with five known triterpenes (4-8). The structures of 1-3 were elucidated by spectral data interpretation. Compounds 1-8 were evaluated for their inhibiting activity against several tumor cell lines and for their effects on lymphocyte proliferation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Chromatography
  • Chromatography, High Pressure Liquid
  • Doxorubicin / pharmacology
  • Drug Resistance, Neoplasm
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • Leukemia P388
  • Leukemia, Lymphoid
  • Magnetic Resonance Spectroscopy
  • Medicine, Chinese Traditional
  • Meliaceae / chemistry*
  • Mice
  • Molecular Structure
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Structure-Activity Relationship
  • Thailand
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology
  • Tumor Cells, Cultured / drug effects
  • Vincristine / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Triterpenes
  • sandorinic acid A
  • sandorinic acid B
  • sandorinic acid C
  • Vincristine
  • Doxorubicin