Pallidal activity is involved in visuomotor association learning in monkeys

Eur J Neurosci. 2001 Sep;14(5):897-901. doi: 10.1046/j.0953-816x.2001.01701.x.


In order to examine whether the basal ganglia are involved in arbitrary visuomotor association, we recorded neuronal activity in the internal segment of the globus pallidus (GPi) of monkeys during a conditional visuomotor learning task. Two monkeys were presented a cueing visual stimulus, and following a delay period required to push, pull or turn a manipulator according to the cue. GPi neurons showed changes in activity during the delay period when the animals performed the task on the basis of a familiar stimulus-response association. Those changes in delay activity were enhanced as the monkeys were learning a new visuomotor association. The enhancement of the changes was selective to a following response. These results suggest that the basal ganglia are involved in arbitrary visuomotor association, especially during the learning of new associations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Association Learning / physiology*
  • Conditioning, Psychological / physiology
  • Globus Pallidus / cytology
  • Globus Pallidus / physiology*
  • Macaca
  • Male
  • Neurons / physiology
  • Psychomotor Performance / physiology*