Physiological aspects of pig-to-primate renal xenotransplantation

Kidney Int. 2001 Oct;60(4):1592-7. doi: 10.1046/j.1523-1755.2001.00973.x.

Abstract

Background: Few data exist on the physiological aspects of pig-to-primate renal xenotransplantation.

Methods: Use of organs transgenic for human decay accelerating factor has allowed assessment of the metabolic and hormonal functions of these xenografts.

Results: Porcine renal xenografts largely maintain plasma electrolyte homeostasis. An increase in proteinuria was detected that may result from graft injury. In contrast to allotransplantation a severe anaemia developed requiring recipient treatment with exogenous human erythropoietin.

Conclusions: Our experience provides qualified encouragement for the likely physiological compatibility of pig and primate species, but identifies areas where a xenograft may not match the performance of an allograft.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia / drug therapy
  • Anemia / etiology
  • Animals
  • Electrolytes / blood
  • Electrolytes / urine
  • Erythropoietin / blood
  • Erythropoietin / therapeutic use
  • Hemoglobins / analysis
  • Humans
  • Kidney / physiopathology*
  • Kidney Transplantation* / adverse effects
  • Macaca fascicularis
  • Proteinuria / etiology
  • Proteinuria / urine
  • Recombinant Proteins / therapeutic use
  • Swine
  • Transplantation, Heterologous*

Substances

  • Electrolytes
  • Hemoglobins
  • Recombinant Proteins
  • Erythropoietin