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, 505 (3), 369-73

Slotoxin, alphaKTx1.11, a New Scorpion Peptide Blocker of MaxiK Channels That Differentiates Between Alpha and Alpha+beta (beta1 or beta4) Complexes

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Slotoxin, alphaKTx1.11, a New Scorpion Peptide Blocker of MaxiK Channels That Differentiates Between Alpha and Alpha+beta (beta1 or beta4) Complexes

J Garcia-Valdes et al. FEBS Lett.

Erratum in

  • FEBS Lett 2001 Oct 19;507(1):122. Possan LD [corrected to Possani LD]

Abstract

A novel peptide from Centruroides noxius Hoffmann scorpion venom was isolated and sequenced. The 37 amino acid peptide belongs to the charybdotoxin sub-family (alphaKTx1) and was numbered member 11. alphaKTx1.11 has 75% sequence identity with iberiotoxin and 54% with charybdotoxin. alphaKTx1.11 revealed specificity for mammalian MaxiK channels (hSlo), thus, was named slotoxin. Slotoxin blocks the MaxiK pore-forming alpha subunit reversibly (K(d)=1.5 nM). Slotoxin association with alpha+beta (beta1 or beta4) channels was approximately 10 times slower than iberiotoxin and charybdotoxin, leading to a lack of effect on alpha+beta4 when tested at 100 nM for 5 min. Thus, slotoxin is a better tool to distinguish MaxiK alpha+beta complexes.

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