Health-related quality of life with coronary heart disease prevention and treatment

J Clin Epidemiol. 2001 Oct;54(10):1011-8. doi: 10.1016/s0895-4356(01)00361-4.


Estimating the net benefits of dyslipidemia treatment is limited by the lack of comprehensive and standardized information on the preference for dyslipidemia and coronary heart disease. In a hospital-based study, we measured the health-related quality of life (HRQOL) of healthy participants without dyslipidemia (n = 307) and with dyslipidemia (n = 251) and patients with coronary heart disease (n = 320). Compared to the healthy participants without dyslipidemia, those with dyslipidemia reported lower adjusted mean scores on the Rating Scale (-2.8 points, P = 0.02) and the SF-36 General Health Scale (-3.3 points, P = 0.02). No differences were observed on the Time Trade-off and the Standard Gamble Scales. Coronary patients reported lower scores on all preference scales and most SF-36 scales. The causes of the small but real reduction in HRQOL reported by dyslipidemic individuals should be identified in order to optimize the net benefits of lipid therapy.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Coronary Disease / complications
  • Coronary Disease / prevention & control*
  • Coronary Disease / psychology
  • Female
  • Humans
  • Hyperlipidemias / complications
  • Hyperlipidemias / prevention & control*
  • Hyperlipidemias / psychology
  • Male
  • Middle Aged
  • Patient Satisfaction*
  • Quality of Life*
  • Quebec