Renal insufficiency accelerates atherosclerosis in patients with type 2 diabetes mellitus

Am J Kidney Dis. 2001 Oct;38(4 Suppl 1):S186-90. doi: 10.1053/ajkd.2001.27440.

Abstract

Diabetes mellitus is a strong risk factor for the progression of atherosclerosis. In patients with chronic renal failure on hemodialysis, advanced atherosclerosis is reported to be present. We examined how renal insufficiency affects intima-medial thickness (IMT) of the carotid and femoral arteries in patients with type 2 diabetes mellitus. IMT was measured by B-mode ultrasonography in 115 patients with type 2 diabetes mellitus (65 men, 50 women; 58 +/- 13 years old). The IMT of the carotid and the femoral artery of patients with creatinine clearance less than 80 mL/min (n = 55) were significantly greater than those of patients with creatinine clearance 80 mL/min or greater (n = 60; P < 0.01 and P < 0.05). Linear regression analyses showed that there was a significant negative correlation between creatinine clearance and IMT of the carotid artery (r = -0.330; P < 0.001) and femoral artery (r = -0.336; P < 0.001). Multiple regression analyses revealed that age and creatinine clearance significantly and independently affected the IMT of the carotid artery (R(2) = 0.176; P < 0.0001), and age, duration of diabetes, and smoking affected the IMT of the femoral artery (R(2) = 0.287; P < 0.0001). These findings show that decreased renal function accelerates atherosclerosis in patients with type 2 diabetes mellitus and that chronic renal failure is a significant, independent risk factor for carotid atherosclerosis in these patients.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Arteriosclerosis / diagnostic imaging*
  • Arteriosclerosis / etiology*
  • Carotid Arteries / diagnostic imaging
  • Creatinine / metabolism
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetic Nephropathies / complications*
  • Female
  • Femoral Artery / diagnostic imaging
  • Humans
  • Kidney Failure, Chronic / complications*
  • Male
  • Middle Aged
  • Regression Analysis
  • Risk Factors
  • Tunica Intima / diagnostic imaging
  • Ultrasonography

Substances

  • Creatinine