Abstract
We measured the membrane current possessing the properties of a mechano-electric transducer current in isolated inner hair cells of guinea-pig cochlea. In a free-standing hair bundle, depolarization to +80 mV evoked a stable outward current attributable to the opening of transducer channels, and repolarization to -80 mV evoked a transient inward current indicating adaptation. The time constant of adaptation increased as the membrane potential depolarized. Dihydrostreptomycin diminished both the outward and inward currents.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Bacterial Agents / pharmacology
-
Cell Membrane / drug effects
-
Cell Membrane / metabolism*
-
Cells, Cultured
-
Dihydrostreptomycin Sulfate / pharmacology
-
Electric Stimulation
-
Guinea Pigs
-
Hair Cells, Auditory, Inner / drug effects
-
Hair Cells, Auditory, Inner / metabolism*
-
Hearing / drug effects
-
Hearing / physiology
-
Ion Channels / drug effects
-
Ion Channels / metabolism*
-
Membrane Potentials / drug effects
-
Membrane Potentials / physiology
-
Signal Transduction / drug effects
-
Signal Transduction / physiology*
Substances
-
Anti-Bacterial Agents
-
Ion Channels
-
Dihydrostreptomycin Sulfate