Expression pattern of Zac1 mouse gene, a new zinc-finger protein that regulates apoptosis and cellular cycle arrest, in both adult brain and along development

Mech Dev. 2001 Oct;108(1-2):207-11. doi: 10.1016/s0925-4773(01)00492-0.


Using in situ hybridization, we analyzed the expression pattern of the Zac1 gene in mouse brain during the embryonic and postnatal development. Zac1 is a new gene that regulates extensive apoptosis and cell cycle arrest through unrelated pathways. At embryonic stages, strong expression was observed in brain areas with active proliferation (ventricular zone and numerous neuroepithelius) and in nervous system (neural retina and neural tube). In addition, some areas with differentiation activity were noticeably labeled such as arcuate nucleus and amygdaloid region of the brain together with other embryonic sites (hindlimb, forelimb and somites). From P0 onwards, the expression appeared in some proliferative areas, such as subventricular zone and cerebellum (external granular layer and Purkinje cells) and in some synaptic plasticity areas, such as the dorso and ventromedial hypothalamic nuclei, arcuate nucleus, ventral thalamic nucleus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Apoptosis / physiology
  • Brain / cytology
  • Brain / embryology*
  • Brain / growth & development*
  • Cell Cycle / genetics
  • Cell Cycle / physiology
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / physiology*
  • Gene Expression Regulation, Developmental
  • Genes, Tumor Suppressor*
  • In Situ Hybridization
  • Mice
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Trans-Activators / genetics*
  • Trans-Activators / physiology*
  • Transcription Factors*
  • Zinc Fingers / genetics
  • Zinc Fingers / physiology


  • Cell Cycle Proteins
  • Plagl1 protein, mouse
  • RNA, Messenger
  • Trans-Activators
  • Transcription Factors