Correlation between 99mTc-pertechnetate uptakes and expressions of human sodium iodide symporter gene in breast tumor tissues

Nucl Med Biol. 2001 Oct;28(7):829-34. doi: 10.1016/s0969-8051(01)00243-8.


We investigated a correlation between the expression of human sodium iodide symporter (hNIS) mRNA and the uptake of 99mTc-pertechnetate in 25 breast tumors. 99mTc-pertechnetate scintigraphy revealed positive uptake in 4 patients. The normalized mRNA expression of hNIS was higher in tumors with positive uptake on the scintigraphy (n=4, median 0.97, range 0.78-1.27) than that in negative uptake tumors (n=21, median 0.46, range 0.10-1.03, p < 0.005). 99mTc-pertechnetate uptake is correlated with the hNIS expression in the breast tumor.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism*
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Middle Aged
  • RNA, Messenger / biosynthesis
  • Radionuclide Imaging
  • Radiopharmaceuticals / pharmacokinetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sodium Pertechnetate Tc 99m / pharmacokinetics*
  • Symporters / biosynthesis
  • Symporters / metabolism*


  • RNA, Messenger
  • Radiopharmaceuticals
  • Symporters
  • sodium-iodide symporter
  • Sodium Pertechnetate Tc 99m