Inflammatory reactions in progressive multifocal leukoencephalopathy after highly active antiretroviral therapy

AIDS. 2001 Sep 28;15(14):1900-2. doi: 10.1097/00002030-200109280-00028.


Three patients with progressive multifocal leukoencephalopathy (PML) treated with highly active antiretroviral therapy (HAART) worsened clinically and radiologically. At the time of deterioration all three had reduced HIV viraemia and increased CD4 cell counts. Brain biopsy in all three disclosed PML and marked perivascular lymphoplasmacytic infiltration. We reviewed the slides of 28 brain biopsies diagnostic of PML. Inflammatory changes were observed in four out of nine patients on HAART and in one out of 19 patients not on HAART.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / immunology
  • Adult
  • Antiretroviral Therapy, Highly Active / adverse effects*
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • Humans
  • Inflammation / etiology*
  • Inflammation / immunology
  • Leukoencephalopathy, Progressive Multifocal / drug therapy*
  • Leukoencephalopathy, Progressive Multifocal / immunology*
  • Male