The enteral insulin-stimulation after Whipple's operation

Diabetologia. 1975 Jun;11(3):207-10. doi: 10.1007/BF00422323.

Abstract

The insulin response to oral and intravenous glucose was measured in ten patients after resection of antrum, duodenum, proximal jejunum, and the head of pancreas (Whipple's operation). Compared to matched normal subjects the operation reduced neither the total nor the gut hormone induced part of the insulin response to oral glucose. The results suggest, that hormones from the first part of the intestinal tract are not necessary as incretins.

MeSH terms

  • Blood Glucose / analysis
  • Digestive System Surgical Procedures*
  • Duodenum / surgery
  • Female
  • Gastrins / physiology
  • Gastrointestinal Hormones / physiology*
  • Glucose / pharmacology*
  • Glucose Tolerance Test
  • Humans
  • Insulin / blood
  • Insulin / metabolism*
  • Insulin Secretion
  • Jejunum / surgery
  • Male
  • Pancreas / surgery
  • Pyloric Antrum / surgery

Substances

  • Blood Glucose
  • Gastrins
  • Gastrointestinal Hormones
  • Insulin
  • Glucose