Polymorphism of the human retinoid X receptor beta and linkage disequilibrium with HLA-DPB1

Tissue Antigens. 2001 Jul;58(1):24-9. doi: 10.1034/j.1399-0039.2001.580104.x.

Abstract

The human retinoid X receptor beta (RXRB) gene is localized in the major histocompatibility complex (MHC) region between DPB1 and RING2. The RXRB gene sequence reported by different investigators suggests that the gene may be polymorphic. In this study, we confirmed one polymorphism by sequencing genomic DNA from four Caucasian individuals. We also developed a restriction fragment length polymorphism (RFLP) analysis to detect this specific polymorphism. Linkage analysis studies between RXRB alleles and a number of HLA markers showed significant linkage disequilibrium between RXRB*T and HLA-DPB1*0401.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Female
  • Gene Frequency / genetics
  • HLA-DP Antigens / genetics*
  • HLA-DP beta-Chains
  • Histocompatibility Testing
  • Humans
  • Linkage Disequilibrium / genetics*
  • Male
  • Pedigree
  • Polymerase Chain Reaction / methods
  • Polymorphism, Genetic / genetics*
  • Polymorphism, Restriction Fragment Length
  • Receptors, Retinoic Acid / genetics*
  • Retinoid X Receptors
  • Sequence Analysis, DNA
  • Transcription Factors / genetics*

Substances

  • HLA-DP Antigens
  • HLA-DP beta-Chains
  • HLA-DPB1 antigen
  • Receptors, Retinoic Acid
  • Retinoid X Receptors
  • Transcription Factors