Modulation of apoptosis during herpes simplex virus infection in human cells

Microbes Infect. 2001 Aug;3(10):859-66. doi: 10.1016/s1286-4579(01)01444-7.


Human herpes simplex virus (HSV) is cytolytic and has profound impacts on its host cells. Consequences of HSV infection include the induction of apoptosis and the concomitant synthesis of proteins which act to block this process. We review recent evidence showing how this important human pathogen modulates the fundamental cell death process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Apoptosis / physiology*
  • Herpes Simplex / virology*
  • Herpesvirus 1, Human / physiology*
  • Humans
  • Virus Replication