IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms

Microbes Infect. 2001 Oct;3(12):1021-35. doi: 10.1016/s1286-4579(01)01460-5.


IgA is the most abundant immunoglobulin produced in mammals; most is secreted as a dimer across mucous membranes. This review discusses the different mechanisms of induction of IgA, and its role in protecting mucosal surfaces against pathogenic and non-pathogenic microorganisms.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / physiology
  • Bile / immunology
  • Humans
  • Immunoglobulin A, Secretory / biosynthesis*
  • Immunoglobulin Class Switching
  • Intestinal Diseases / immunology
  • Intestinal Mucosa / immunology*
  • Intestines / microbiology
  • Milk / immunology
  • Rotavirus Infections / immunology


  • Immunoglobulin A, Secretory