Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 121 (5), 569-72

Drug-induced Otoxicity: Current Status


Drug-induced Otoxicity: Current Status

V Palomar García et al. Acta Otolaryngol.


We carried out a review of the literature published over the last 10 years on drug-induced ototoxicity by means of a Medline search using the terms 'clinical ototoxicity' for the period January 1990 to September 2000 and found 414 published articles. In order to summarize the content of these articles, we asked ourselves a series of nine questions and answered them based on the most widely-held views and those we considered of greatest interest in the articles reviewed. The questions asked were: what are the most commonly used ototoxic drugs? what is the site of action of ototoxic drugs? what is the importance of the dose and dosing interval? does age influence ototoxicity? are all humans equally prone to the ototoxic effects of drugs? are there substances that are protective against ototoxicity? can hearing loss be monitored? should hearing loss be attributed to ototoxic drugs in all cases? and is ototoxicity in animals the same as in humans?

Similar articles

  • Aminoglycoside-induced Ototoxicity
    E Selimoglu. Curr Pharm Des 13 (1), 119-26. PMID 17266591. - Review
    It has long been known that the major irreversible toxicity of aminoglycosides is ototoxicity. Among them, streptomycin and gentamicin are primarily vestibulotoxic, where …
  • [Adverse Effects of Drugs on the Hearing Organ]
    K Mees. Laryngol Rhinol Otol (Stuttg) 65 (7), 363-70. PMID 3528724. - Review
    Many different classes of drugs are known to produce ototoxicity. They include such commonly used agents as salicylates and diuretics but the most important of them are t …
  • [Ototoxic Drugs. I. Aminoglycoside Antibiotics]
    E Buszman et al. Wiad Lek 56 (5-6), 254-9. PMID 14526485. - Review
    The fact that some drugs can affect the hearing function is well known. All aminoglycoside antibiotics have the potential to induce severe and irreversible ototoxicity in …
  • [Threshold Doses in Ototoxicity]
    P Federspil. HNO 32 (10), 417-8. PMID 6334677.
    In the introduction the main importance of the total dose of administered aminoglycoside antibiotics for ototoxicity is stressed. Within the clinical ototoxicity dose ran …
  • Ototoxicity Resulting From Combined Administration of Cisplatin and Gentamicin
    S Kohn et al. Laryngoscope 107 (3), 407-8. PMID 9121325.
See all similar articles

Cited by 10 PubMed Central articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources