Common themes in mechanisms of gene silencing

Mol Cell. 2001 Sep;8(3):489-98. doi: 10.1016/s1097-2765(01)00340-9.

Abstract

The assembly of DNA into regions of inaccessible chromatin, called silent chromatin, is involved in the regulation of gene expression and maintenance of chromosome stability in eukaryotes. Recent studies on Sir2-containing silencing complexes in budding yeast and HP1- and Swi6-containing silencing complexes in metazoans and fission yeast suggest a common mechanism for the assembly of these domains, which involves the physical coupling of histone modifying enzymes to histone binding proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromatin / metabolism
  • Chromosomal Proteins, Non-Histone / metabolism
  • Fungal Proteins
  • Gene Expression Regulation / physiology
  • Gene Silencing*
  • Histone Deacetylases / metabolism
  • Histones / metabolism
  • Humans
  • RNA, Ribosomal / genetics
  • RNA, Ribosomal / metabolism
  • Saccharomyces cerevisiae Proteins*
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae*
  • Sirtuin 1
  • Sirtuin 2
  • Sirtuins
  • Trans-Activators / metabolism
  • Transcription Factors
  • Yeasts / genetics

Substances

  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Fungal Proteins
  • Histones
  • RNA, Ribosomal
  • SWI6 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae
  • Trans-Activators
  • Transcription Factors
  • SIR2 protein, S cerevisiae
  • SIRT1 protein, human
  • Sirtuin 1
  • Sirtuin 2
  • Sirtuins
  • Histone Deacetylases