Short-echo time proton MR spectroscopy in the presence of gadolinium

J Comput Assist Tomogr. Sep-Oct 2001;25(5):705-12. doi: 10.1097/00004728-200109000-00007.


Purpose: The purpose of this work was to quantify the impact of contrast agents on short-TE single-voxel 1H MR spectroscopy (MRS) diagnosis of recurrent brain tumors.

Method: Short-TE 1H MRS was performed in 49 patients with biopsy-proven brain tumors and 14 control subjects. Eight patients (nine paired exams) were examined before and after administration of Gd-DTPA (interval approximately 5-7 min).

Results: Tumor spectra showed increased choline/creatine ratio (Cho/Cr; p < 0.009) and Cho concentrations (p < 0.02). Receiver operator characteristic for Cho/Cr = 0.93 differentiated 100% of tumors from control in the absence or presence of contrast agent. Repeated 1H MRS varied <3%. Cho T2 was significantly longer than Cr T2 (p < 0.02).

Conclusion: Proton MRS with TE of 30 ms may safely be used in combined contrast-enhanced MRI/MRS protocols. Further study is required with long-TE MRS because of the prolonged T2 of Cho.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Brain Neoplasms / diagnostic imaging*
  • Contrast Media / administration & dosage
  • Female
  • Gadolinium*
  • Humans
  • Kinetics
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Middle Aged
  • Protons
  • Radionuclide Imaging
  • Sensitivity and Specificity
  • Time Factors


  • Contrast Media
  • Protons
  • Gadolinium