The endocytic pathway: a mosaic of domains

Nat Rev Mol Cell Biol. 2001 Oct;2(10):721-30. doi: 10.1038/35096054.


Organelles in the endocytic pathway are composed of a mosaic of structural and functional regions. These regions consist, at least in part, of specialized protein-lipid domains within the plane of the membrane, or of protein complexes associated with specific membrane lipids. Whereas some of these molecular assemblies can be found in more than one compartment, a given combination seems to be unique to each compartment, indicating that membrane organization might be modular.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Endocytosis / physiology*
  • Endosomes / physiology
  • Humans
  • Mammals
  • Models, Biological
  • Saccharomyces cerevisiae / physiology
  • Signal Transduction / physiology