The INK4a/ARF network in tumour suppression

Nat Rev Mol Cell Biol. 2001 Oct;2(10):731-7. doi: 10.1038/35096061.


The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.

Publication types

  • Review

MeSH terms

  • ADP-Ribosylation Factor 1 / physiology*
  • Animals
  • Cyclin-Dependent Kinase Inhibitor p16 / physiology*
  • Genes, Retinoblastoma
  • Genes, Tumor Suppressor*
  • Genes, p53
  • Humans
  • Models, Biological
  • Neoplasms / prevention & control*
  • Signal Transduction


  • Cyclin-Dependent Kinase Inhibitor p16
  • ADP-Ribosylation Factor 1