A decade of CDK5

Nat Rev Mol Cell Biol. 2001 Oct;2(10):749-59. doi: 10.1038/35096019.

Abstract

Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction. Recent evidence indicates that deregulation of this kinase is involved in the pathology of neurodegenerative diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • CDC2-CDC28 Kinases*
  • Cell Cycle / physiology*
  • Central Nervous System / physiology
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinase 5
  • Cyclin-Dependent Kinases / metabolism
  • Cyclin-Dependent Kinases / physiology*
  • Dopamine / physiology
  • Humans
  • Models, Biological
  • Neurons / physiology
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / metabolism
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / physiology
  • Signal Transduction

Substances

  • Cyclin-Dependent Kinase 5
  • Protein-Serine-Threonine Kinases
  • CDC2-CDC28 Kinases
  • CDK2 protein, human
  • CDK5 protein, human
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinases
  • Dopamine