PKB/AKT: functional insights from genetic models

Nat Rev Mol Cell Biol. 2001 Oct;2(10):760-8. doi: 10.1038/35096067.


Since its discovery 10 years ago, the potential functions of protein kinase B (PKB)/AKT have been catalogued with increasing efficiency. The physiological relevance of some of the proposed mechanisms by which PKB/AKT mediates many of its effects has been questioned, and recent work using new reagents and approaches has revealed some cracks in our understanding of this important molecule, and also hinted that these effects may involve other players.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Drosophila / genetics
  • Drosophila Proteins
  • Enzyme Activation
  • Humans
  • Models, Biological
  • Models, Genetic
  • Molecular Sequence Data
  • Phosphatidylinositol 3-Kinases / metabolism
  • Protein Serine-Threonine Kinases*
  • Protein-Tyrosine Kinases / metabolism
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-akt
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Substrate Specificity


  • Drosophila Proteins
  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • AKT1 protein, human
  • Akt1 protein, Drosophila
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt