The Renaissance of GSK3

Nat Rev Mol Cell Biol. 2001 Oct;2(10):769-76. doi: 10.1038/35096075.

Abstract

Glycogen synthase kinase 3 (GSK3) was initially described as a key enzyme involved in glycogen metabolism, but is now known to regulate a diverse array of cell functions. The study of the substrate specificity and regulation of GSK3 activity has been important in the quest for therapeutic intervention.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Drosophila melanogaster / embryology
  • Embryo, Nonmammalian / physiology
  • Enzyme Inhibitors / pharmacology
  • Glycogen / biosynthesis
  • Glycogen Synthase Kinases
  • Humans
  • Insulin / physiology
  • Phosphorylation
  • Protein Biosynthesis
  • Signal Transduction
  • Substrate Specificity

Substances

  • Enzyme Inhibitors
  • Insulin
  • Glycogen
  • Glycogen Synthase Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases