Behavioral characterization of dopamine D5 receptor null mutant mice

Behav Neurosci. 2001 Oct;115(5):1129-44.


To study behavioral functions of the D5 subtype, mice were generated with null mutations in the D5 gene. This 1st behavioral characterization of D5 null mutant mice (D5-/-) indicated normal general health, sensory abilities, and neurological reflexes. Under basal conditions, D5-/- mice were generally normal on locomotor activity, the rotarod test, acoustic startle response, prepulse inhibition, elevated plus-maze, light <--> dark exploration, Morris water maze, and cued and contextual fear conditioning. In the Porsolt forced swim test for antidepressant activity, male D5-/- mice showed lower levels of immobility. D5-/- mice showed some evidence of reduced responses to the hyperactivity-inducing effects of the D1/D5 receptor agonist SKF 81297. The ability of SKF 81297 to disrupt acoustic startle and prepulse inhibition appeared to be attenuated in D5-/- mice. These results suggest that the D5 receptor is not essential for many dopamine-mediated behaviors but may contribute to the pharmacological activation of dopaminergic pathways relevant to exploratory locomotion, startle, and prepulse inhibition.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Arousal / genetics
  • Arousal / physiology
  • Behavior, Animal / physiology*
  • Brain / physiology
  • Exploratory Behavior / physiology
  • Female
  • Locomotion / physiology
  • Male
  • Maze Learning / physiology
  • Mice
  • Mice, Knockout
  • Mice, Neurologic Mutants
  • Motivation
  • Neural Inhibition / physiology
  • Receptors, Dopamine D1 / genetics*
  • Receptors, Dopamine D1 / physiology
  • Receptors, Dopamine D5
  • Reflex, Startle / physiology


  • Drd5 protein, mouse
  • Receptors, Dopamine D1
  • Receptors, Dopamine D5