Neurons in the lateral paragigantocellular nucleus (LPGi) are known to project directly to the infralimbic cortex (IL). However, there have been no physiological studies on LPGi neurons projecting to the IL. In urethane-anesthetized rats, the single-unit activities of LPGi neurons were recorded extracellularly to investigate their electrophysiological properties and responses to changes in blood pressure (BP). The LPGi neurons antidromically driven from the IL were restricted to the ventral part of the LPGi and most spontaneously active neurons revealed suppression of activity following a fall in BP. These results suggest that the LPGi neurons in a very restricted location influence the IL in response to changes in BP.