BRCA1-associated tumorigenesis: what have we learned from knockout mice?

Trends Genet. 2001 Oct;17(10):S18-22. doi: 10.1016/s0168-9525(01)02451-9.


A series of allelic mutations in the tumor suppressor Brca1 have been created to study mechanisms underlying BRCA1-associated tumorigenesis. Brca1 is essential in maintaining genome integrity through its involvement in DNA damage repair, G(2)-M cell-cycle checkpoint and centrosome duplication. The loss of Brca1 is not sufficient for malignant transformation, rather, it triggers multiple genetic alterations, including the inactivation of p53 and activation of a number of oncogenes, that ultimately result in mammary tumorigenesis.

Publication types

  • Review

MeSH terms

  • Alleles
  • Animals
  • Breast Neoplasms / etiology
  • Breast Neoplasms / genetics*
  • Female
  • Genes, BRCA1*
  • Genes, p53
  • Humans
  • Mammary Neoplasms, Experimental / etiology
  • Mammary Neoplasms, Experimental / genetics*
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Mutation