Abstract
Our understanding of body weight regulation has been greatly advanced by the characterization of previously existing mutations in mice that cause obesity. Subsequent analysis of a number of mouse knockout models has greatly expanded the number of genes known to influence adiposity by affecting metabolic rate, physical activity, and/or appetite.
MeSH terms
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Animals
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Disease Models, Animal
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Gonadal Steroid Hormones / genetics
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Humans
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Mice
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Mice, Knockout
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Neuropeptide Y / genetics
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Neurotransmitter Agents / genetics
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Obesity / etiology
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Obesity / genetics*
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Pro-Opiomelanocortin / genetics
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Receptors, Adrenergic, beta-3 / genetics
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Receptors, Corticotropin / genetics
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Receptors, Cytoplasmic and Nuclear / genetics
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Receptors, Melanocortin
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Receptors, Neuropeptide Y / genetics
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Transcription Factors / genetics
Substances
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Gonadal Steroid Hormones
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Neuropeptide Y
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Neurotransmitter Agents
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Receptors, Adrenergic, beta-3
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Receptors, Corticotropin
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Receptors, Cytoplasmic and Nuclear
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Receptors, Melanocortin
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Receptors, Neuropeptide Y
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Transcription Factors
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Pro-Opiomelanocortin