Knockout models resulting in the development of obesity

Trends Genet. 2001 Oct;17(10):S50-4. doi: 10.1016/s0168-9525(01)02481-7.

Abstract

Our understanding of body weight regulation has been greatly advanced by the characterization of previously existing mutations in mice that cause obesity. Subsequent analysis of a number of mouse knockout models has greatly expanded the number of genes known to influence adiposity by affecting metabolic rate, physical activity, and/or appetite.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Gonadal Steroid Hormones / genetics
  • Humans
  • Mice
  • Mice, Knockout
  • Neuropeptide Y / genetics
  • Neurotransmitter Agents / genetics
  • Obesity / etiology
  • Obesity / genetics*
  • Pro-Opiomelanocortin / genetics
  • Receptors, Adrenergic, beta-3 / genetics
  • Receptors, Corticotropin / genetics
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Melanocortin
  • Receptors, Neuropeptide Y / genetics
  • Transcription Factors / genetics

Substances

  • Gonadal Steroid Hormones
  • Neuropeptide Y
  • Neurotransmitter Agents
  • Receptors, Adrenergic, beta-3
  • Receptors, Corticotropin
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Melanocortin
  • Receptors, Neuropeptide Y
  • Transcription Factors
  • Pro-Opiomelanocortin