Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities

C N Backhouse; C L Delporte; R E Negrete; S Erazo; A Zuñiga; A Pinto; B K Cassels

doi:10.1016/s0378-8741(01)00309-9

Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities

J Ethnopharmacol. 2001 Nov;78(1):27-31. doi: 10.1016/s0378-8741(01)00309-9.

Authors

C N Backhouse¹, C L Delporte, R E Negrete, S Erazo, A Zuñiga, A Pinto, B K Cassels

Affiliation

¹ Laboratory of Pharmacognosy, Faculty of Pharmaceutical and Chemical Sciences, University of Chile, PO Box 233, 1-, Santiago, Chile.

PMID: 11585684
DOI: 10.1016/s0378-8741(01)00309-9

Abstract

The antiinflammatory and antipyretic activities of the petroleum ether extract (PEE), dichloromethane extract (DME) and methanol extract (ME1) of the aerial part of Psoralea glandulosa L. (Papilionaceae) were studied. The bioactivity-guided fractionation of the active extracts yielded the isolation of bakuchiol (Bk) from the petroleum ether as the active compound, cyclobakuchiols A and B (Cbk), and angelicin (Ang) from DME.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analgesics, Non-Narcotic / chemistry*
Analgesics, Non-Narcotic / isolation & purification
Analgesics, Non-Narcotic / pharmacology*
Animals
Anti-Inflammatory Agents, Non-Steroidal / chemistry*
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Edema / chemically induced
Edema / prevention & control
Ethers
Female
Guinea Pigs
Magnetic Resonance Spectroscopy
Male
Methanol
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plants, Medicinal / chemistry*
Psoralea / chemistry*
Rabbits
Solvents

Substances

Analgesics, Non-Narcotic
Anti-Inflammatory Agents, Non-Steroidal
Ethers
Plant Extracts
Solvents
Methanol